Across TCGA pan-cancer cohorts, CCSER1 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated CCSER1 data layer compared with 26 for mass-spec protein and 2 for mass-spec protein.
The strongest signal is observed in breast invasive carcinoma (BRCA), where higher CCSER1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CCSER1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and COAD show a favorable association.
BRCA, UCEC, and DLBC are the cancer types where CCSER1 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.