CCR6

Across TCGA cell cohorts, CCR6 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCR6-associated genes across cancer lineages are UTF1, MAGEB5, and IL26. Each is linked with CCR6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCR6-to-partner and partner-to-CCR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UTF1 grouped by CCR6-low versus CCR6-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCR6→partner) and Y-score (partner→CCR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	UTF1 →	+0.136	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LARGE_INTESTINE	IL26 →	+0.564	+3.793	<.001	.007	3	1
LARGE_INTESTINE	UNC5D →	+0.052	+4.032	<.001	.004	3	1
CNS	LACRT →	+0.278	+4.981	<.001	.008	3	1
LARGE_INTESTINE	DIPK2B →	+0.065	+4.357	<.001	.004	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

UTF1 by CCR6 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →