CCR5

Across TCGA cell cohorts, CCR5 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CCR5-associated genes across cancer lineages are DIRC1, OR4F4, and VN1R3. Each is linked with CCR5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCR5-to-partner and partner-to-CCR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DIRC1 grouped by CCR5-low versus CCR5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCR5→partner) and Y-score (partner→CCR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DIRC1 →	+0.005	+5.022	<.001	.002	3	1
LARGE_INTESTINE	OR4F4 →	+0.017	+4.273	.001	.006	3	1
LARGE_INTESTINE	VN1R3 →	+0.015	+5.022	<.001	.002	3	1
LARGE_INTESTINE	RTP2 →	+0.013	+5.217	.001	<.001	3	1
LARGE_INTESTINE	OR6Q1 →	+0.022	+5.022	<.001	.002	3	1
CNS	VN1R4 →	+0.098	+5.754	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

DIRC1 by CCR5 expression — LARGE_INTESTINE

Explore this box plot interactively →