CCNL1

Across TCGA pan-cancer cohorts, CCNL1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CCNL1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CCNL1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CCNL1 is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

HNSC, CCRCC, and LSCC are the cancer types where CCNL1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCNL1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.282	<.001	8	view →
CCRCC	Male	All	+0.220	<.001	6	view →
LSCC	Male	All	+0.249	<.001	5	view →
OV	All	All	+0.438	.034	2	view →
LUAD	Female	All	−0.159	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CCNL1–HNSC

Open the HNSC breakdown →