CCNK

Across TCGA cell cohorts, CCNK mutation is significantly associated with the drug of many other genes, with 28 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCNK-associated genes across cancer lineages are Niraparib, FGFR_3831, and Ruxolitinib. Each is linked with CCNK in more than 1 cancer types. Because this analysis shows association rather than direction, both CCNK-to-partner and partner-to-CCNK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Niraparib grouped by CCNK-low versus CCNK-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCNK→partner) and Y-score (partner→CCNK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Niraparib →	+0.472	+2.678	.007	.037	3	1
LARGE_INTESTINE	FGFR_3831 →	+0.590	+2.649	.027	.046	3	1
LARGE_INTESTINE	Ruxolitinib →	+0.392	+2.646	.009	.047	3	1
LARGE_INTESTINE	OSI-027 →	+0.439	+2.769	.044	.040	3	1
LARGE_INTESTINE	150412 →	+0.379	+2.777	.024	.038	3	1
LARGE_INTESTINE	KIN001-244 →	+0.415	+2.652	.042	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Niraparib by CCNK expression — LARGE_INTESTINE

Explore this box plot interactively →