CCNK

Across TCGA pan-cancer cohorts, CCNK RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CCNK’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CCNK RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CCNK is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, BLCA, and THCA are the cancer types where CCNK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCNK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.744	<.001	11	view →
BLCA	Male	III,IV	+0.715	<.001	11	view →
THCA	All	All	−0.495	<.001	9	view →
STAD	All	II,III,IV	+0.649	<.001	7	view →
LUSC	Male	II,III,IV	+0.585	<.001	7	view →
KIRP	All	II,III,IV	+0.493	.007	7	view →
BRCA	All	II,III,IV	+0.473	<.001	6	view →
LIHC	All	All	+0.369	<.001	6	view →
CHOL	All	All	+0.900	.003	4	view →
ESCA	All	All	+0.699	.013	2	view →
LUAD	All	All	+0.217	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CCNK–HNSC

Open the HNSC breakdown →