CCNI

Across TCGA patient cohorts, CCNI mutation is significantly associated with the RNA expression of many other genes, with 344 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCNI-associated genes across cancer lineages are COX15, CHEK1, and DUSP15. Each is linked with CCNI in more than 1 cancer types. Because this analysis shows association rather than direction, both CCNI-to-partner and partner-to-CCNI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX15 grouped by CCNI-low versus CCNI-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCNI→partner) and Y-score (partner→CCNI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COX15 →	+0.491	+3.329	.004	.005	3	1
UCEC	CHEK1 →	+0.721	+2.606	.003	.006	3	1
UCEC	DUSP15 →	-0.854	-3.678	.006	.001	3	1
UCEC	ALDOA →	+0.566	+3.700	.006	.001	3	1
UCEC	GUF1 →	+0.691	+3.711	<.001	<.001	3	1
UCEC	HAUS1 →	+0.774	+3.343	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 344 associations by consensus.

COX15 by CCNI expression — UCEC

Explore this box plot interactively →