CCNI

Across TCGA patient cohorts, CCNI mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCNI-associated genes across cancer lineages are FoxM1, MEK1, and PCNA. Each is linked with CCNI in more than 1 cancer types. Because this analysis shows association rather than direction, both CCNI-to-partner and partner-to-CCNI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by CCNI-low versus CCNI-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCNI→partner) and Y-score (partner→CCNI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.267	+3.584	.033	.002	3	1
UCEC	MEK1 →	+0.464	+2.459	.008	.020	3	1
UCEC	PCNA →	+0.279	+2.459	.007	.020	3	1
UCEC	PDCD4 →	-0.681	-3.312	.002	.010	3	1
UCEC	VHL →	-0.943	-3.169	.004	.019	3	1
UCEC	4E-BP1_pT37_T46 →	-0.494	-2.459	.006	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

FoxM1 by CCNI expression — UCEC

Explore this box plot interactively →