CCNI

Across TCGA cell cohorts, CCNI RNA expression is significantly associated with the go_rna of many other GO terms, with 3,668 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CCNI-associated GO terms across cancer lineages are Negative regulation of transcription by RNA polymerase I, Vesicle coating, and DAMP biosynthetic process. Each is linked with CCNI in more than 12 cancer types. Because this analysis shows association rather than direction, both CCNI-to-partner and partner-to-CCNI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of transcription by RNA polymerase I grouped by CCNI-low versus CCNI-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCNI→partner) and Y-score (partner→CCNI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of transcription by RNA polymerase I →	+0.111	+0.699	<.001	<.001	3	12
LUNG_SCLC	Vesicle coating →	+0.075	+0.433	.004	.005	2	13
LARGE_INTESTINE	DAMP biosynthetic process →	+0.121	+0.637	<.001	<.001	3	11
BONE	COPII-coated vesicle budding →	+0.093	+0.781	.001	<.001	3	11
LARGE_INTESTINE	Purine deoxyribonucleoside monophosphate biosynthetic process →	+0.121	+0.637	<.001	<.001	3	11
LARGE_INTESTINE	Vesicle budding from membrane →	+0.087	+0.820	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,668 associations by consensus.

Negative regulation of transcription by RNA polymerase I by CCNI expression — OVARY

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