CCNF

Across TCGA patient cohorts, CCNF mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCNF-associated genes across cancer lineages are Rab25, C-Raf, and PCNA. Each is linked with CCNF in more than 2 cancer types. Because this analysis shows association rather than direction, both CCNF-to-partner and partner-to-CCNF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab25 grouped by CCNF-low versus CCNF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCNF→partner) and Y-score (partner→CCNF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab25 →	-0.482	-3.321	<.001	.009	3	3
UCEC	C-Raf →	+0.143	+2.000	.011	.010	3	3
COAD	PCNA →	+0.284	+2.815	.036	.036	3	2
COAD	XBP1 →	+0.293	+2.815	.005	.036	3	2
UCEC	EGFR_pY1068 →	-0.257	-2.502	.009	.002	3	2
UCEC	p62 Lck ligand →	+0.343	+2.000	.007	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Rab25 by CCNF expression — UCEC

Explore this box plot interactively →