CCNF

Across TCGA pan-cancer cohorts, CCNF RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated CCNF data layer compared with 9 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher CCNF RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CCNF expression acts as an unfavorable survival marker, although some lineages such as SCLC and THYM show a favorable association.

KIRP, MESO, and ACC are the cancer types where CCNF RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.764	0.933	<.001	154	view →
MESO	OS	Median	All	0.367	0.712	<.001	141	view →
ACC	DFS	Median	All	0.417	0.745	<.001	137	view →
KIRC	DFS	Tertile	All	0.524	0.708	<.001	132	view →
LIHC	DFS	Median	All	0.454	0.625	<.001	90	view →
LGG	OS	Median	All	0.383	0.520	<.001	51	view →
THCA	DFS	Tertile	II,III,IV	0.739	0.919	.001	47	view →
SARC	OS	Quartile	All	0.655	0.871	<.001	36	view →
UCEC	DFS	Tertile	All	0.793	0.900	.002	32	view →
KICH	OS	Tertile	All	0.740	1.000	.008	31	view →
PAAD	DFS	Median	All	0.246	0.492	.001	31	view →
SKCM	OS	Median	All	0.268	0.430	<.001	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

CCNF–KIRP (DFS)

Open the KIRP breakdown →