CCNF

Across TCGA cell cohorts, CCNF mutation is significantly associated with the RNA expression of many other genes, with 229 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CCNF-associated genes across cancer lineages are MEIKIN, DEFB108B, and GSG1L. Each is linked with CCNF in more than 1 cancer types. Because this analysis shows association rather than direction, both CCNF-to-partner and partner-to-CCNF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEIKIN grouped by CCNF-low versus CCNF-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCNF→partner) and Y-score (partner→CCNF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MEIKIN →	+0.357	+4.087	<.001	.009	3	2
CNS	DEFB108B →	+0.042	+4.169	<.001	.008	3	2
BLOOD_Leukemia	GSG1L →	+0.276	+3.510	<.001	.003	3	2
BLOOD_Leukemia	PRND →	+0.007	+3.611	<.001	<.001	3	2
BLOOD_Leukemia	OR5P3 →	+0.045	+3.201	<.001	.005	3	2
URINARY_TRACT	GJD2 →	+0.034	+4.217	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 229 associations by consensus.

MEIKIN by CCNF expression — URINARY_TRACT

Explore this box plot interactively →