CCNE2

Across TCGA patient cohorts, CCNE2 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCNE2-associated genes across cancer lineages are JNK_pT183_Y185, MEK1, and Notch1. Each is linked with CCNE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCNE2-to-partner and partner-to-CCNE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by CCNE2-low versus CCNE2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCNE2→partner) and Y-score (partner→CCNE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.244	-2.446	.002	.020	3	1
UCEC	MEK1 →	+0.469	+2.459	.007	.020	3	1
UCEC	Notch1 →	+0.223	+2.459	.001	.020	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.505	-2.446	.020	.020	3	1
UCEC	p38-MAPK →	-0.177	-2.979	.026	.036	3	1
UCEC	Tuberin →	+0.266	+2.459	.041	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

JNK_pT183_Y185 by CCNE2 expression — UCEC

Explore this box plot interactively →