CCNE1

Across TCGA patient cohorts, CCNE1 mutation is significantly associated with the RNA expression of many other genes, with 3,060 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCNE1-associated genes across cancer lineages are FAM27B, MIR3660, and MIR2115. Each is linked with CCNE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCNE1-to-partner and partner-to-CCNE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM27B grouped by CCNE1-low versus CCNE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCNE1→partner) and Y-score (partner→CCNE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FAM27B →	+0.051	+2.699	<.001	.003	3	2
CESC	MIR3660 →	+0.290	+4.539	<.001	.008	3	2
BLCA	MIR2115 →	+0.460	+6.814	<.001	<.001	3	2
UCEC	RN7SL478P →	+0.156	+1.491	.002	.009	3	2
UCEC	GNPNAT1 →	+0.809	+2.069	<.001	<.001	3	2
UCEC	PRORP →	+0.314	+2.069	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,060 associations by consensus.

FAM27B by CCNE1 expression — UCEC

Explore this box plot interactively →