CCND3

Across TCGA patient cohorts, CCND3 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCND3-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR, and ERK2. Each is linked with CCND3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCND3-to-partner and partner-to-CCND3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CCND3-low versus CCND3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCND3→partner) and Y-score (partner→CCND3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.563	+2.189	.041	.034	3	2
UCEC	EGFR →	-0.190	-3.000	.010	.036	3	1
UCEC	ERK2 →	+0.276	+3.321	.002	.010	3	1
UCEC	FoxM1 →	+0.248	+2.584	.039	.011	3	1
UCEC	mTOR_pS2448 →	-0.168	-2.302	.015	.034	3	1
UCEC	PCNA →	+0.314	+3.700	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Caspase-7-cleavedD198 by CCND3 expression — UCEC

Explore this box plot interactively →