CCND3

Across TCGA pan-cancer cohorts, CCND3 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of CCND3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CCND3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CCND3 is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

KIRC, LIHC, and LUAD are the cancer types where CCND3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCND3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.905	<.001	12	view →
LIHC	Female	II,III,IV	+1.281	<.001	9	view →
LUAD	Female	II,III,IV	−0.958	<.001	9	view →
THCA	Male	All	+0.759	<.001	9	view →
KICH	Female	II,III,IV	−2.107	<.001	8	view →
LUSC	Female	II,III,IV	−2.038	<.001	8	view →
BRCA	Female	II,III,IV	−0.442	<.001	6	view →
UCEC	All	All	−0.966	<.001	4	view →
STAD	All	II,III,IV	+0.635	.001	4	view →
CHOL	All	All	+2.476	<.001	3	view →
KIRP	All	III,IV	+0.669	.012	3	view →
HNSC	Male	All	+0.419	.013	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

CCND3–KIRC

Open the KIRC breakdown →