CCNB3

Across TCGA patient cohorts, CCNB3 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCNB3-associated genes across cancer lineages are 53BP1, eIF4E, and C-Raf. Each is linked with CCNB3 in more than 3 cancer types. Because this analysis shows association rather than direction, both CCNB3-to-partner and partner-to-CCNB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 53BP1 grouped by CCNB3-low versus CCNB3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCNB3→partner) and Y-score (partner→CCNB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	53BP1 →	+0.355	+2.321	.047	.034	3	4
UCEC	eIF4E →	+0.194	+1.662	<.001	<.001	3	4
UCEC	C-Raf →	+0.101	+1.241	.006	.012	3	4
UCEC	Caspase-7-cleavedD198 →	+0.734	+1.662	<.001	<.001	3	3
UCEC	Bcl-2 →	-0.257	-1.632	.004	.005	3	3
UCEC	eEF2 →	+0.218	+1.247	.018	.038	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

53BP1 by CCNB3 expression — STAD

Explore this box plot interactively →