CCNB3

Across TCGA pan-cancer cohorts, CCNB3 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CCNB3’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CCNB3 RNA is repressed in tumor relative to normal tissue. In most cancer types CCNB3 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, LIHC, and KICH are the cancer types where CCNB3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCNB3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−0.287	<.001	10	view →
LIHC	Male	II,III,IV	+0.414	<.001	8	view →
KICH	All	All	−0.373	<.001	7	view →
BRCA	All	All	+0.209	<.001	6	view →
CHOL	All	All	+0.263	.005	5	view →
STAD	Male	All	+0.224	.009	4	view →
READ	Male	All	+0.189	.013	4	view →
LUSC	All	III,IV	−0.304	.007	3	view →
COAD	All	All	+0.079	.019	3	view →
KIRP	Female	II,III,IV	+0.650	.030	2	view →
UCEC	All	All	+0.319	.004	2	view →
PRAD	All	All	+0.142	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CCNB3–THCA

Open the THCA breakdown →