CCNB1

Across TCGA patient cohorts, CCNB1 mutation is significantly associated with the RNA expression of many other genes, with 2,165 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCNB1-associated genes across cancer lineages are HMGN1P19, SNRPCP20, and LSP1P1. Each is linked with CCNB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCNB1-to-partner and partner-to-CCNB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGN1P19 grouped by CCNB1-low versus CCNB1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCNB1→partner) and Y-score (partner→CCNB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	HMGN1P19 →	+0.048	+4.147	.005	.009	3	2
UCEC	SNRPCP20 →	+0.210	+2.311	<.001	.004	3	2
UCEC	LSP1P1 →	+0.313	+2.284	<.001	.004	3	2
UCEC	RNU6-131P →	+0.357	+2.539	<.001	.003	3	2
UCEC	IGLVI-38 →	+0.096	+2.424	.005	.005	3	2
LGG	TEX101P1 →	+0.169	+7.977	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,165 associations by consensus.

HMGN1P19 by CCNB1 expression — BLCA

Explore this box plot interactively →