CCNB1

Across TCGA pan-cancer cohorts, CCNB1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of CCNB1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CCNB1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CCNB1 is over-expressed in tumor.

HNSC, LUAD, and BLCA are the cancer types where CCNB1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCNB1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.861	<.001	12	view →
LUAD	Male	III,IV	+3.560	<.001	11	view →
BLCA	Male	III,IV	+3.428	<.001	11	view →
COAD	Female	II,III,IV	+1.955	<.001	11	view →
KIRP	Male	III,IV	+1.826	<.001	11	view →
KIRC	Male	IV	+1.211	<.001	11	view →
LUSC	Male	III,IV	+4.029	<.001	9	view →
LIHC	Female	II,III,IV	+2.843	<.001	9	view →
STAD	Female	All	+2.808	<.001	8	view →
UCEC	All	III,IV	+3.519	<.001	6	view →
BRCA	All	III,IV	+2.470	<.001	6	view →
CHOL	Male	All	+4.446	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

CCNB1–HNSC

Open the HNSC breakdown →