CCNB1

Across TCGA patient cohorts, CCNB1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCNB1-associated genes across cancer lineages are Ku80, Paxillin, and PREX1. Each is linked with CCNB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCNB1-to-partner and partner-to-CCNB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by CCNB1-low versus CCNB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCNB1→partner) and Y-score (partner→CCNB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.263	+2.472	.021	.011	3	1
UCEC	Paxillin →	+0.266	+2.459	.034	.020	3	1
UCEC	PREX1 →	-0.319	-3.000	.016	.036	3	1
UCEC	ASNS →	+0.430	+2.459	.013	.020	3	1
UCEC	YB-1 →	+0.175	+2.486	.022	.011	3	1
UCEC	Bap1-c-4 →	+0.248	+2.189	.019	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Ku80 by CCNB1 expression — UCEC

Explore this box plot interactively →