CCNA1

Across TCGA patient cohorts, CCNA1 mutation is significantly associated with the RNA expression of many other genes, with 1,109 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCNA1-associated genes across cancer lineages are SERP2, VANGL2, and SLIT2-IT1. Each is linked with CCNA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCNA1-to-partner and partner-to-CCNA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SERP2 grouped by CCNA1-low versus CCNA1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCNA1→partner) and Y-score (partner→CCNA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SERP2 →	-1.065	-3.558	.001	.003	3	3
UCEC	VANGL2 →	-0.804	-2.486	.001	.001	3	3
HNSC	SLIT2-IT1 →	+0.147	+3.364	<.001	.007	3	2
BLCA	MIR4779 →	+0.331	+4.497	<.001	.009	3	2
UCEC	NOCT →	+0.775	+2.332	<.001	<.001	3	2
UCEC	SLC25A27 →	-0.649	-2.799	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,109 associations by consensus.

SERP2 by CCNA1 expression — COAD

Explore this box plot interactively →