CCNA1

Across TCGA pan-cancer cohorts, CCNA1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CCNA1 data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CCNA1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CCNA1 expression acts as an unfavorable survival marker, although some lineages such as CHOL and BRCA show a favorable association.

HNSC, KIRC, and MESO are the cancer types where CCNA1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.704	0.797	<.001	145	view →
KIRC	DFS	Median	All	0.532	0.703	<.001	132	view →
MESO	DFS	Tertile	IV	0.196	0.572	.001	86	view →
STAD	OS	Median	All	0.628	0.740	.006	71	view →
UVM	DFS	Median	II,III,IV	0.336	0.751	.002	62	view →
BLCA	DFS	Quartile	II,III,IV	0.540	0.699	.004	51	view →
LGG	OS	Median	All	0.745	0.872	<.001	37	view →
CHOL	DFS	Median	All	0.721	0.106	<.001	30	view →
BRCA	DFS	Tertile	All	0.650	0.460	.005	25	view →
SCLC	DFS	Quartile	II,III,IV	0.800	0.183	.001	22	view →
UCEC	OS	Median	All	0.761	0.588	.007	22	view →
KIRP	OS	Quartile	All	0.886	0.999	.004	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CCNA1–HNSC (OS)

Open the HNSC breakdown →