CCN3

Across TCGA pan-cancer cohorts, CCN3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CCN3 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CCN3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CCN3 expression acts as an unfavorable survival marker.

LUAD, LSCC, and PDAC are the cancer types where CCN3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.846	0.997	<.001	44	view →
LSCC	OS	Tertile	II,III,IV	0.698	1.000	.002	23	view →
PDAC	DFS	Median	All	0.296	0.424	.017	7	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CCN3–LUAD (DFS)

Open the LUAD breakdown →