CCN3

Across TCGA pan-cancer cohorts, CCN3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CCN3’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CCN3 RNA is repressed in tumor relative to normal tissue. In most cancer types CCN3 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LIHC are the cancer types where CCN3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCN3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−1.527	<.001	9	view →
KICH	Female	II,III,IV	−2.468	<.001	7	view →
LIHC	Male	II,III,IV	+0.896	<.001	7	view →
BRCA	All	III,IV	−1.453	<.001	6	view →
LUSC	Male	III,IV	−2.687	.015	5	view →
READ	Female	All	−2.013	<.001	5	view →
KIRC	Male	II,III,IV	−0.908	<.001	5	view →
LUAD	Female	All	−0.775	<.001	5	view →
KIRP	Female	II,III,IV	+2.397	.009	4	view →
UCEC	All	All	−1.040	.013	4	view →
CHOL	All	All	+1.982	<.001	3	view →
ESCA	Female	All	−2.056	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CCN3–THCA

Open the THCA breakdown →