CCN3

Across TCGA cell cohorts, CCN3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,017 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CCN3-associated GO terms across cancer lineages are Negative regulation of sensory perception of pain, Regulation of matrix metallopeptidase secretion, and Positive regulation of cell-matrix adhesion. Each is linked with CCN3 in more than 17 cancer types. Because this analysis shows association rather than direction, both CCN3-to-partner and partner-to-CCN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of sensory perception of pain grouped by CCN3-low versus CCN3-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCN3→partner) and Y-score (partner→CCN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Negative regulation of sensory perception of pain →	+1.887	+3.366	<.001	<.001	3	18
BONE	Regulation of matrix metallopeptidase secretion →	-0.292	-2.759	<.001	<.001	3	8
BREAST	Positive regulation of cell-matrix adhesion →	+0.136	+2.090	<.001	<.001	3	7
BREAST	Positive regulation of translational initiation →	+0.048	+1.117	.006	.008	3	7
LIVER	Negative regulation of protein export from nucleus →	+0.118	+2.059	<.001	.001	3	7
SOFT_TISSUE	Negative regulation of protein catabolic process →	+0.072	+2.086	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,017 associations by consensus.

Negative regulation of sensory perception of pain by CCN3 expression — CNS

Explore this box plot interactively →