CCM2L

Across TCGA patient cohorts, CCM2L mutation is significantly associated with the RNA expression of many other genes, with 181 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CCM2L-associated genes across cancer lineages are RNU1-27P, RPS27P18, and SNORD126. Each is linked with CCM2L in more than 1 cancer types. Because this analysis shows association rather than direction, both CCM2L-to-partner and partner-to-CCM2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-27P grouped by CCM2L-low versus CCM2L-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCM2L→partner) and Y-score (partner→CCM2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU1-27P →	+0.169	+3.682	<.001	.004	3	2
SKCM	RPS27P18 →	+0.137	+3.744	<.001	.003	3	2
HNSC	SNORD126 →	+0.681	+3.847	<.001	.006	3	2
HNSC	RNU7-161P →	+0.322	+5.023	<.001	.003	3	2
SKCM	ASS1P8 →	+0.035	+4.302	<.001	.007	3	2
SKCM	MIR4510 →	+0.148	+5.163	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 181 associations by consensus.

RNU1-27P by CCM2L expression — SKCM

Explore this box plot interactively →