CCM2L

Across TCGA pan-cancer cohorts, CCM2L RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CCM2L’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CCM2L RNA is repressed in tumor relative to normal tissue. In most cancer types CCM2L is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, COAD, and LUAD are the cancer types where CCM2L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCM2L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.778	<.001	11	view →
COAD	Female	II,III,IV	−0.630	<.001	11	view →
LUAD	Female	III,IV	−2.683	<.001	9	view →
KIRP	Male	All	−1.822	<.001	9	view →
LUSC	Male	All	−2.370	<.001	8	view →
BLCA	All	III,IV	−0.942	.002	8	view →
LIHC	Female	All	+0.818	<.001	8	view →
UCEC	All	All	−1.890	<.001	6	view →
BRCA	All	II,III,IV	−1.396	<.001	6	view →
THCA	All	IV	−1.082	.003	6	view →
KIRC	All	All	+0.485	<.001	4	view →
READ	Female	All	−1.109	.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CCM2L–KICH

Open the KICH breakdown →