CCM2L

Across TCGA patient cohorts, CCM2L mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. COAD shows the largest number of these associations.

The most reproducible CCM2L-associated genes across cancer lineages are C-Raf_pS338, Chk1, and eIF4E. Each is linked with CCM2L in more than 1 cancer types. Because this analysis shows association rather than direction, both CCM2L-to-partner and partner-to-CCM2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf_pS338 grouped by CCM2L-low versus CCM2L-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCM2L→partner) and Y-score (partner→CCM2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C-Raf_pS338 →	+0.229	+2.815	.009	.036	3	1
COAD	Chk1 →	+0.354	+2.815	.003	.036	2	1
COAD	eIF4E →	+0.275	+2.832	.005	.035	1	1
COAD	4E-BP1_pT70 →	+0.131	+2.815	.045	.036	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

C-Raf_pS338 by CCM2L expression — COAD

Explore this box plot interactively →