CCM2L

Across TCGA cell cohorts, CCM2L mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCM2L-associated genes across cancer lineages are CCL17, SLC6A2, and USP26. Each is linked with CCM2L in more than 1 cancer types. Because this analysis shows association rather than direction, both CCM2L-to-partner and partner-to-CCM2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL17 grouped by CCM2L-low versus CCM2L-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCM2L→partner) and Y-score (partner→CCM2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CCL17 →	+0.369	+3.845	<.001	.001	3	1
KIDNEY	SLC6A2 →	+0.051	+3.369	<.001	.003	3	1
KIDNEY	USP26 →	+0.015	+3.369	.004	.003	3	1
KIDNEY	KLK3 →	+0.259	+2.947	<.001	.009	3	1
KIDNEY	DPT →	+0.021	+4.108	<.001	.005	3	1
KIDNEY	CNTNAP4 →	+0.014	+2.947	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

CCL17 by CCM2L expression — KIDNEY

Explore this box plot interactively →