CCL8

Across TCGA patient cohorts, CCL8 mutation is significantly associated with the RNA expression of many other genes, with 103 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CCL8-associated genes across cancer lineages are MIR6090, MIR5708, and CTBP2P9. Each is linked with CCL8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCL8-to-partner and partner-to-CCL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6090 grouped by CCL8-low versus CCL8-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCL8→partner) and Y-score (partner→CCL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MIR6090 →	+0.567	+5.033	<.001	.009	3	2
HNSC	MIR5708 →	+0.268	+7.954	<.001	.008	3	2
SKCM	CTBP2P9 →	+0.066	+4.665	<.001	<.001	3	2
SKCM	E2F6P1 →	+0.043	+4.179	<.001	.001	3	2
UCEC	RNA5SP411 →	+1.497	+3.130	<.001	.003	3	1
LIHC	OR4D6 →	+0.048	+5.268	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 103 associations by consensus.

MIR6090 by CCL8 expression — LIHC

Explore this box plot interactively →