CCL8

Across TCGA pan-cancer cohorts, CCL8 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CCL8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CCL8 RNA is repressed in tumor relative to normal tissue. In most cancer types CCL8 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, COAD, and LIHC are the cancer types where CCL8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCL8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	II,III,IV	−2.357	<.001	11	view →
COAD	Male	All	−1.927	<.001	10	view →
LIHC	All	II,III,IV	+0.783	.001	8	view →
KIRP	All	All	−0.969	<.001	7	view →
BRCA	All	III,IV	−1.304	<.001	6	view →
CHOL	All	All	+1.227	.002	3	view →
BLCA	All	All	−0.882	.047	2	view →
ESCA	All	All	+0.831	.024	2	view →
READ	Female	All	−1.804	.004	1	view →
LUAD	All	All	+0.562	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CCL8–KICH

Open the KICH breakdown →