CCL4

Across TCGA patient cohorts, CCL4 mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCL4-associated genes across cancer lineages are CMP, Endothelial cells, and Erythrocytes. Each is linked with CCL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCL4-to-partner and partner-to-CCL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CMP grouped by CCL4-low versus CCL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCL4→partner) and Y-score (partner→CCL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CMP →	+0.037	+2.332	.014	.020	3	1
UCEC	Endothelial cells →	-0.039	-2.279	.040	.036	3	1
UCEC	Erythrocytes →	+0.037	+2.321	.002	.036	2	2
UCEC	Neutrophils →	+0.021	+1.681	<.001	.049	3	1
UCEC	pDC →	+0.064	+3.032	.008	.018	3	1
UCEC	Skeletal muscle →	+0.075	+3.470	<.001	.003	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CMP by CCL4 expression — UCEC

Explore this box plot interactively →