CCL4

Across TCGA pan-cancer cohorts, CCL4 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated CCL4 data layer compared with 2 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher CCL4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CCL4 expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCEC show a favorable association.

SKCM, UVM, and UCEC are the cancer types where CCL4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.455	0.244	<.001	151	view →
UVM	DFS	Tertile	All	0.371	0.793	<.001	99	view →
UCEC	DFS	Median	All	0.881	0.793	.001	78	view →
THYM	OS	Median	All	0.743	1.000	.001	43	view →
KIRP	DFS	Tertile	III,IV	0.452	0.818	.004	40	view →
LUSC	DFS	Tertile	II,III,IV	0.492	0.851	.005	24	view →
CHOL	DFS	Median	All	0.668	0.169	.001	12	view →
KIRC	DFS	Quartile	All	0.719	0.861	.007	10	view →
THCA	DFS	Quartile	III,IV	0.925	0.511	.019	9	view →
GBM	DFS	Quartile	All	0.138	0.241	.009	6	view →
SCLC	DFS	Median	II,III,IV	0.925	0.486	.016	6	view →
LGG	OS	Quartile	All	0.951	0.839	.002	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

CCL4–SKCM (OS)

Open the SKCM breakdown →