CCL2

Across TCGA patient cohorts, CCL2 mutation is significantly associated with the RNA expression of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCL2-associated genes across cancer lineages are RNU6-675P, OR2D2, and INO80B-WBP1. Each is linked with CCL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCL2-to-partner and partner-to-CCL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-675P grouped by CCL2-low versus CCL2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCL2→partner) and Y-score (partner→CCL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-675P →	+0.241	+4.771	<.001	.006	3	2
UCEC	OR2D2 →	+0.098	+3.048	.009	.002	3	1
UCEC	INO80B-WBP1 →	+0.152	+3.670	<.001	.002	3	1
UCEC	MIR6795 →	+0.285	+5.060	<.001	.001	3	1
SKCM	LINC02420 →	+0.098	+5.402	<.001	.001	3	1
SKCM	FKBP1AP2 →	+0.166	+5.682	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

RNU6-675P by CCL2 expression — SKCM

Explore this box plot interactively →