CCL2

Across TCGA pan-cancer cohorts, CCL2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CCL2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CCL2 RNA is repressed in tumor relative to normal tissue. In most cancer types CCL2 is over-expressed in tumor, although a few such as KICH and HNSC show the opposite, repressed pattern.

KICH, HNSC, and BLCA are the cancer types where CCL2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCL2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−5.077	<.001	11	view →
HNSC	All	II,III,IV	−1.210	<.001	10	view →
BLCA	All	All	−2.297	<.001	9	view →
LUSC	Male	II,III,IV	−2.146	<.001	6	view →
UCEC	All	All	−1.506	.003	6	view →
BRCA	All	III,IV	−1.446	<.001	6	view →
LIHC	Male	All	−1.334	<.001	4	view →
KIRP	All	II,III,IV	−1.196	.024	2	view →
THCA	Female	All	−1.105	.002	2	view →
LUAD	All	All	−0.638	.010	2	view →
STAD	Female	III,IV	+1.065	.022	1	view →
KIRC	Female	All	+1.015	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CCL2–KICH

Open the KICH breakdown →