CCL2

Across TCGA cell cohorts, CCL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,677 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CCL2-associated GO terms across cancer lineages are Negative regulation of lymphocyte chemotaxis, Regulation of natural killer cell chemotaxis, and Substrate adhesion-dependent cell spreading. Each is linked with CCL2 in more than 14 cancer types. Because this analysis shows association rather than direction, both CCL2-to-partner and partner-to-CCL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of lymphocyte chemotaxis grouped by CCL2-low versus CCL2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCL2→partner) and Y-score (partner→CCL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of lymphocyte chemotaxis →	+1.906	+4.471	<.001	<.001	3	15
LIVER	Regulation of natural killer cell chemotaxis →	+1.850	+4.615	<.001	<.001	3	14
BONE	Substrate adhesion-dependent cell spreading →	+0.126	+1.851	.002	.008	3	11
LIVER	Oncostatin-M-mediated signaling pathway →	+0.271	+4.605	<.001	.001	3	11
BONE	Positive regulation of apoptotic cell clearance →	+1.741	+4.194	<.001	<.001	3	11
URINARY_TRACT	Golgi to plasma membrane protein transport →	+0.098	+2.707	.003	.006	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,677 associations by consensus.

Negative regulation of lymphocyte chemotaxis by CCL2 expression — LIVER

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