CCL15-CCL14

Across TCGA pan-cancer cohorts, CCL15-CCL14 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CCL15-CCL14’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CCL15-CCL14 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CCL15-CCL14 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

KIRC, COAD, and KICH are the cancer types where CCL15-CCL14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCL15-CCL14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	+0.960	<.001	12	view →
COAD	Female	III,IV	−2.080	<.001	11	view →
KICH	All	II,III,IV	−1.011	<.001	7	view →
LUSC	All	II,III,IV	−0.599	<.001	7	view →
LUAD	Female	All	−0.447	<.001	7	view →
STAD	All	II,III,IV	+0.939	<.001	6	view →
KIRP	All	II,III,IV	−0.807	.009	6	view →
ESCA	All	II,III,IV	+1.474	.007	4	view →
READ	All	All	−1.061	.004	4	view →
UCEC	All	All	−0.391	.003	4	view →
CHOL	All	All	−1.464	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CCL15-CCL14–KIRC

Open the KIRC breakdown →