CCKAR

Across TCGA pan-cancer cohorts, CCKAR Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CCKAR data layer compared with 19 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CCKAR Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated CCKAR expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

UCEC, READ, and STAD are the cancer types where CCKAR Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.624	.006	30	view →
READ	OS	Median	III,IV	0.328	0.751	<.001	22	view →
STAD	DFS	Median	III,IV	1.000	0.314	.025	12	view →
LUSC	DFS	Median	II,III,IV	0.242	0.596	.024	12	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.014	6	view →
SKCM	OS	Median	All	0.953	0.867	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CCKAR–UCEC (DFS)

Open the UCEC breakdown →