CCKAR

Across TCGA pan-cancer cohorts, CCKAR RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of CCKAR’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CCKAR RNA is repressed in tumor relative to normal tissue. In most cancer types CCKAR is over-expressed in tumor, although a few such as KIRC and STAD show the opposite, repressed pattern.

KIRC, STAD, and KIRP are the cancer types where CCKAR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCKAR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−0.215	<.001	12	view →
STAD	All	IV	−3.293	<.001	9	view →
KIRP	Male	All	−0.173	<.001	6	view →
BRCA	All	II,III,IV	+0.167	<.001	6	view →
KICH	All	All	+1.942	<.001	5	view →
PRAD	All	All	+0.065	.040	2	view →
ESCA	All	All	−3.070	.011	1	view →
COAD	All	II,III,IV	−0.212	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

CCKAR–KIRC

Open the KIRC breakdown →