CCKAR

Across TCGA pan-cancer cohorts, CCKAR mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated CCKAR data layer compared with 19 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher CCKAR mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CCKAR expression acts as an unfavorable survival marker.

PDAC are the cancer types where CCKAR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.219	0.988	.010	14	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

CCKAR–PDAC (DFS)

Open the PDAC breakdown →