CCKAR

Across TCGA patient cohorts, CCKAR mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCKAR-associated genes across cancer lineages are EGFR, Caspase-7-cleavedD198, and p38-MAPK_pT180_Y182. Each is linked with CCKAR in more than 1 cancer types. Because this analysis shows association rather than direction, both CCKAR-to-partner and partner-to-CCKAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by CCKAR-low versus CCKAR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCKAR→partner) and Y-score (partner→CCKAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.213	-2.558	<.001	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.430	+1.604	.040	.041	3	2
SKCM	p38-MAPK_pT180_Y182 →	-0.317	-1.906	.023	.016	3	2
SKCM	Rab11 →	-0.171	-2.459	.035	.018	3	2
LUAD	p70-S6K →	+0.242	+3.169	.022	.018	3	1
UCEC	14-3-3_beta →	-0.090	-2.432	.011	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

EGFR by CCKAR expression — UCEC

Explore this box plot interactively →