CCKAR

Across TCGA cell cohorts, CCKAR RNA expression is significantly associated with the go_rna of many other GO terms, with 603 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CCKAR-associated GO terms across cancer lineages are RNA export from nucleus, Calcium ion transmembrane transport, and Ventricular cardiac muscle cell differentiation. Each is linked with CCKAR in more than 3 cancer types. Because this analysis shows association rather than direction, both CCKAR-to-partner and partner-to-CCKAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA export from nucleus grouped by CCKAR-low versus CCKAR-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCKAR→partner) and Y-score (partner→CCKAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	RNA export from nucleus →	+0.062	+0.005	.009	.008	3	4
LUNG_SCLC	Calcium ion transmembrane transport →	-0.030	-0.584	.004	.004	3	4
BLOOD_Lymphoma	Ventricular cardiac muscle cell differentiation →	-0.154	-0.005	.004	.008	3	3
LUNG_SCLC	Protein polyubiquitination →	+0.032	+0.642	.008	.001	3	3
OVARY	Negative regulation of humoral immune response mediated by circulating immunoglobulin →	-0.284	-0.092	<.001	.005	3	3
LUNG_SCLC	Middle ear morphogenesis →	-0.910	-0.472	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 603 associations by consensus.

RNA export from nucleus by CCKAR expression — BLOOD_Lymphoma

Explore this box plot interactively →