CCKAR

Across TCGA cell cohorts, CCKAR mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CCKAR-associated genes across cancer lineages are MAGEB4, NPHS2, and CSN2. Each is linked with CCKAR in more than 1 cancer types. Because this analysis shows association rather than direction, both CCKAR-to-partner and partner-to-CCKAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by CCKAR-low versus CCKAR-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCKAR→partner) and Y-score (partner→CCKAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.014	+4.000	<.001	<.001	3	2
SKIN	NPHS2 →	+0.017	+4.415	<.001	.007	3	1
SKIN	CSN2 →	+0.078	+4.415	<.001	.007	3	1
SKIN	OR5A1 →	+0.015	+5.022	<.001	.002	3	1
SKIN	TFAP2D →	+0.142	+4.415	<.001	.007	3	1
BLOOD_Leukemia	NR4A3 →	+0.294	+3.328	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

MAGEB4 by CCKAR expression — LARGE_INTESTINE

Explore this box plot interactively →