CCKAR

Across TCGA cell cohorts, CCKAR mutation is significantly associated with the mutation status of many other genes, with 2,876 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCKAR-associated genes across cancer lineages are NRK, KIF26B, and MAP1S. Each is linked with CCKAR in more than 4 cancer types. Because this analysis shows association rather than direction, both CCKAR-to-partner and partner-to-CCKAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NRK grouped by CCKAR-low versus CCKAR-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCKAR→partner) and Y-score (partner→CCKAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	NRK →	+3.357	+4.285	.005	.005	1	5
STOMACH	KIF26B →	+2.942	+4.025	.009	.009	1	4
LUNG_NSCLC_LUAD	MAP1S →	+4.772	+5.339	.004	.004	1	4
SKIN	RSF1 →	+5.053	+4.239	.007	.007	1	4
BLOOD_Leukemia	KRT15 →	+4.794	+3.309	.002	.002	1	4
BLOOD_Leukemia	NPR1 →	+5.531	+3.799	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,876 associations by consensus.

NRK by CCKAR expression — STOMACH

Explore this box plot interactively →