Across TCGA cell cohorts, CCK RNA expression is significantly associated with the go_rna of many other GO terms, with 2,429 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CCK-associated GO terms across cancer lineages are Cholecystokinin signaling pathway, Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, and Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Each is linked with CCK in more than 15 cancer types. Because this analysis shows association rather than direction, both CCK-to-partner and partner-to-CCK results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCK→partner) and Y-score (partner→CCK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Cholecystokinin signaling pathway →	+2.108	+5.287	<.001	<.001	3	16
SKIN	Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.070	+0.338	<.001	.004	2	8
SOFT_TISSUE	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum →	+0.074	+0.245	<.001	.003	3	6
SOFT_TISSUE	Positive regulation of post-translational protein modification →	+0.066	+0.204	<.001	.002	3	6
SOFT_TISSUE	Positive regulation of protein modification by small protein conjugation or removal →	+0.069	+0.211	<.001	.001	3	6
LUNG_NSCLC_LUAD	Negative regulation of response to endoplasmic reticulum stress →	+0.064	+1.132	.003	.004	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,429 associations by consensus.

Exploration

CCK survival (RNA) · tumor vs normal (RNA) · all CCK data types