Across TCGA pan-cancer cohorts, CCK RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of CCK’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CCK RNA is repressed in tumor relative to normal tissue. In most cancer types CCK is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.
KIRC, THCA, and LUAD are the cancer types where CCK tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCK RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.