CCDC96

Across TCGA pan-cancer cohorts, CCDC96 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated CCDC96 data layer compared with 1 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher CCDC96 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CCDC96 expression acts as an unfavorable survival marker, although some lineages such as BRCA and UCEC show a favorable association.

BRCA, UCEC, and PAAD are the cancer types where CCDC96 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Tertile	III,IV	0.896	0.744	.003	55	view →
UCEC	OS	Tertile	All	0.797	0.697	.002	54	view →
PAAD	OS	Quartile	All	0.697	0.245	<.001	43	view →
LGG	DFS	Median	All	0.667	0.805	<.001	42	view →
MESO	OS	Tertile	IV	0.168	0.756	.001	42	view →
CESC	OS	Tertile	III,IV	0.727	0.207	.007	34	view →
KIRP	DFS	Tertile	All	1.000	0.778	.007	22	view →
CHOL	OS	Median	III,IV	1.000	0.286	.008	15	view →
ACC	OS	Quartile	III,IV	1.000	0.477	.023	15	view →
LUAD	OS	Median	III,IV	0.498	0.817	<.001	14	view →
GBM	OS	Tertile	All	0.339	0.574	.007	12	view →
DLBC	DFS	Median	All	1.000	0.635	.019	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

CCDC96–BRCA (OS)

Open the BRCA breakdown →