CCDC96

Across TCGA pan-cancer cohorts, CCDC96 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CCDC96’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CCDC96 RNA is repressed in tumor relative to normal tissue. In most cancer types CCDC96 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and LUAD are the cancer types where CCDC96 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC96 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	−1.020	<.001	10	view →
COAD	Female	II,III,IV	−0.750	<.001	10	view →
LUAD	Female	All	−1.015	<.001	9	view →
LUSC	All	II,III,IV	−1.056	<.001	6	view →
LIHC	Female	II,III,IV	+0.604	<.001	6	view →
BRCA	All	All	+0.498	<.001	6	view →
READ	All	All	−0.805	<.001	5	view →
CHOL	All	All	+0.892	<.001	4	view →
PAAD	All	All	+0.394	.031	2	view →
STAD	All	II,III,IV	+0.369	.030	2	view →
KICH	All	II,III,IV	−0.451	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CCDC96–THCA

Open the THCA breakdown →