Across TCGA pan-cancer cohorts, CCDC96 mass-spec protein differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of CCDC96’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where CCDC96 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CCDC96 is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.
LUAD are the cancer types where CCDC96 tumor–normal differential expression is most reproducible.